p53: Guardian of the Genome

p53: Guardian of the Genome

nature video

2 года назад

79,003 Просмотров

The tumour-suppressing protein called p53, also known as the guardian of the genome, protects our cells from cellular damage. Under cellular stress, p53 jumps into action, regulating gene expression to control DNA repair, cell division and cell death.

But, p53 malfunction is associated with a vast array of difficult to treat cancers, and these can arise either from mutations in the TP53 gene, or through an overabundance of a regulatory protein that keeps p53 inactive. Unfortunately, there are no catch-all drugs to tackle these types of cancer, but several combination therapies are undergoing research, offering hope for the future.

Read more in https://www.nature.com/collections/p53-outline

This Nature Video is editorially independent. It is produced with third party financial support. Read more about Supported Content here: https://partnerships.nature.com/commercial-content-at-nature-research/

Sign up for the Nature Briefing: An essential round-up of science news, opinion and analysis, free in your inbox every weekday: https://go.nature.com/371OcVF

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Комментарии:

Amru Magdy
Amru Magdy - 21.10.2023 21:41

الله

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elizabeth elson
elizabeth elson - 21.10.2023 09:00

Thanks for simplyfying the topic in this way...and making it understandable 🙏😊

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sooooooooDark
sooooooooDark - 23.08.2023 10:53

fun fact: genistein (from soy) apigenin (from parsley) and oroxylin A (from bBaikal skullcap) increase p53 expression
the more u know

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Lisa Di Gangi
Lisa Di Gangi - 20.08.2023 18:23

how would the drug selinexor work in regards to maintenence therapy for endometrial cancer? I'm trying to learn more for my mom who is in treatment for the disease now. We are beginning the selinexor clinical trial soon. I like to understand things so I can have questions ready for the dr. Thanks everyone. :)

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ℙ𝕌𝔹𝕃𝕀ℂ ℂℍ𝔸ℕℕ𝔼𝕃
ℙ𝕌𝔹𝕃𝕀ℂ ℂℍ𝔸ℕℕ𝔼𝕃 - 25.04.2023 16:45

Super 🎉🎉🎉🎉

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Chris
Chris - 10.02.2023 07:05

Intro goes hard asf

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flaminmongrel
flaminmongrel - 16.12.2022 15:23

this reminds me of the presentation in the first Jurassic park movie

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bigfootpegrande
bigfootpegrande - 25.09.2022 15:58

Amen

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Shahir Khan  🇧🇩
Shahir Khan 🇧🇩 - 13.03.2022 17:13

Great way of representation!

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D D
D D - 07.03.2022 10:56

why someone spent all this effort on "woke" art style to anthromorphise a molecule rather than using that effort to try to help people get a visual concept of the actual conformation of the protein is beyond me. you people will insert politics at every possible opportunity even if it means diluting your message

>sponsored by a pharma company involved in immuontherapies for cancer ..... oh it makes more sense now why your p53 is a thicc bipoc female who promotes immunotherapies

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Armando Pérez Gutiérrez
Armando Pérez Gutiérrez - 06.03.2022 19:23

Good video

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平和
平和 - 04.03.2022 19:28

Nice art style, very well explained!

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Charvy R
Charvy R - 04.03.2022 18:43

I really liked the creative take on such a complex topic. Am thrilled how innovatively some of this protein's mechanisms are presented in here! Doesn't cover the whole story but anyone interested in learning the very basic might find it useful. As someone who submitted their thesis on p53, this was actually refreshing to watch.

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The Sheekey Science Show
The Sheekey Science Show - 04.03.2022 13:56

This is the protein i study :D

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Mufaddal Manaquib
Mufaddal Manaquib - 03.03.2022 16:11

Lovely

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tbird81
tbird81 - 03.03.2022 12:30

The silly animation doesn't really explain anything. There's a better video on P53 on the "But Why?" Channel.

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jörg methfessel
jörg methfessel - 03.03.2022 11:40

after the robot i stopped listening, of course i watched the video till the end :D

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Thomas Bingel
Thomas Bingel - 03.03.2022 10:17

Too cartoonish! Did not like it! Perhaps, nice for teenagers!

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raag
raag - 03.03.2022 05:17

Is it Apo-ptosis? Or a-pop-tosis?

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Ethan
Ethan - 03.03.2022 01:15

I thought this was about the PS3 when I first read the title...

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Carlos Fernando Castañeda Olano
Carlos Fernando Castañeda Olano - 02.03.2022 22:52

Excellent animation. Thank you so much. Greetings from Bimac research group at Universidad del Cauca, Colombia.

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Paula Z. Flaquer
Paula Z. Flaquer - 02.03.2022 21:49

Great animation!

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bhargavi kulkarni
bhargavi kulkarni - 02.03.2022 19:54

Amazingly visualized! Great work!

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Solace Easy
Solace Easy - 02.03.2022 19:38

50 years and millions to study something caused likely by the chemical and electromagnetic pollution surrounding us. Can't fix that, so add more chemicals.

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J
J - 02.03.2022 18:48

Matrix Neo Trinity Morpheus P53... fighting evil... guarding and restoring..cell life!!

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Önder Kirca
Önder Kirca - 02.03.2022 18:24

By far the best medical animation I've ever watched. Thanks to those who contributed. The adventure of understanding p53 continues...

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ELΞCTROBLADE
ELΞCTROBLADE - 02.03.2022 18:13

I Really Liked The Idea Where The P53 Gene And The Cancer Fighting Super Duo Are Superheroes, Nice Touch

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Rylac Zero
Rylac Zero - 02.03.2022 17:55

Didn't hear a word. I was focused on the animation. Nice job.

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Holy Diver
Holy Diver - 02.03.2022 17:43

Awesome video!

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negar toorany
negar toorany - 02.03.2022 17:33

it was really good! great job! please do more of these videos

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Amadioh FIXED
Amadioh FIXED - 02.03.2022 17:26

I admire to be like p53

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NSXTypeRGTRLM
NSXTypeRGTRLM - 02.03.2022 17:25

While in medical school we had a security guard that would always give us a hard time even when we had our IDs on us. We lovingly called her p53.

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Shubham Barik
Shubham Barik - 02.03.2022 17:11

Great video

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hatib muhamad
hatib muhamad - 02.03.2022 17:08

Wow! the best science communication of the year so far

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