Understanding & Conquering Depression

Very interesting video. I'm currently trying to understand my own mental health and am 21. I think I've got a form of depression but not clinical depression.

Essential Phatty Acids

You are awesome!

PLEASE DO A POD ON BENZODIAZEPINE WITHDRAWAL. This is the new Opioid epidemic. Makes coming off all other meds feel like a beautiful day at the beach. We really need more info put out there. Thank you.

Dr Huberman, thank you so much for this. You are a great teacher. Kind karma. Donna

Andrew, you’re one of the people the universe blesses the rest of us with. 🙏🏻

Is Lexapro a good drug for major depression? I am on day 4 today

Guess who´s back,, hahahahah, I´m your fan number one, greetings, hughes and the best wishes for you my professor, master I´d like to share you all my recent book that´s related to your topics and field, I´m profesor too and you´re my daily roomate hahaha btw I´m from Colombia and currently living here

🐇🐇🐇

I think what makes me depressed is that I am lonely as heck and can't find my beautiful partner man.

I am in the 1/3 of the population for whom SSRI’s had no positive effect, and in fact caused profound harm including daily rumination on death and suicidal ideation—for hours and hours a day, for 5 years. I renegades with life Only when I stopped taking both antidepressants I was prescribed—as the primary one needed a ‘booster’ to ‘help’ it. This 1/3 of the population that gets labeled ‘treatment resistant’ is most probably a much higher percentage, as doctors don’t traditionally like reporting they were unable to move the needle on a patient’s wellness. My feeling is that the number is probably more like 50%. Additionally, there is no mention of what may be responsible with respect to why this class of drugs works for some people—belief. Simply put, some patients put enormous faith in what they are told. And when they believe wholesale what their prescribing doctors tell them, their belief overrides the lack of actual improvement and they report and perceive themselves as feeling better. Vilify me if you will—6 years of my precious life were taken by an array of psychopharmeceuticals flattening my aspect to the point that I was very nearly non-verbal for 18 months, ruminating all day on death. Reversal only occurred when I stopped ingesting these toxic compounds. Body work, mindfulness, energy work—these modalities are THE frontline modalities to turn to when a pervasive low mood first presents. No one can say I don’t know what I am talking about and that I don’t have credentials to back up what I’m saying. I walked this path personally. What psychiatrist or psychopharmacologist or exert out there espousing the befits of compounds taht flatten aspect, inspire suicidal ideation and worse, can say that they’ve submitted themselves to these compounds for years in order to amplify their BOOK learning? I’d venture to say that figure is zero.

Ppl have to stop using word depression loosely. Because is much more bigger then just a bad mood. There r number of symptoms, feels like your brain got sick and u can’t handle it that’s why want it to end. I know from my experience

Shout out to the ones with depression that made it through this entire video 😅

I click with everything you said. Thats sad :( its super hard to control, but i keep going everyday even though im not happy. I miss feeling happy. I 🙏 for everyone to have a healthy life and i hope yall never feel like this.

Is it OK to take venlafaxine with 125mg of natural GABA?

You mentioned that people with depression have a cortisol peak at 9pm - do you have advice on how to manage this? Is this something that will 'normalise' if the symptoms of depression are managed/ reduced or is this something that will always remain ? Should people continue with the morning protocols you discuss (in other episodes) or try something slightly different? thanks!

Me watching this while taking my SSRIs

What about MCT? Can that fall in the EPA CHAIN? Since its a medium Chain triglyceride its not?

5 -10 mg daily Creatine Monohydrate, EPA (not DHA) omega oil, and exercise are the recommendations he gives for depression .
Let me add those to my Zoloft, 5htp, cordycep mushroom, Sam-e, mood boost digestive supplement and green juice .
Ugh. I just want to not suffer depression and anxiety 🙃

I would love to see a show on benzodiazepines.

Great podcast. Riveted.

Can we ask if you can make podcast on schizophrenia? 🙏🏻🙏🏻🙏🏻🙏🏻🙏🏻🕊️🕊️

What about Low Dose Naltrexone?

Thank you for speaking on so many relevant topics and providing implementable strategies.

I wonder when spirituality and the Self in the world becomes a factor of consideration regarding depression. Perhaps that it is linked to a Bigger picture aspect of being here in this world and all the chemical and neurological signs are just symptoms of a deeper issue pertaining to one's existence here. I think there is a lot to regard with philosophers like Schopenhauer and Nietzsche with relevance to personal power and asserting oneself as being necessary parts of a healthy psychology that is condemned as egotism/evil when it is a vital fundamental in a world that for the most part is wholly adversarial to everything living within it.

Not relevant but, his pen clip looks weird

Thanks for creating this, Dr. Huberman! Your contribution to science and humanity is wonderful. Hoping these notes can help others summarize this great information :)

Types of depression
1 Major depression
Unipolar (lows)

2 Bipolar depression
High
Low

Chemicals of depression
1 Norepinephrine
Psychomotor retardation, can’t get out of bed, lethargy

2 Dopamine
No motivation to do anything
Lack of ability to experience pleasure - anhedonia

3 Serotonin
Grief and guilt, emotional aspect

Other factors relating to depression
4 Pain (pleasure and pain scale and homeostasis)

5 Hormones
Low thyroid hormone, hypothyroidism, Hashimoto thyroiditis, thyroid related to metabolism

6 Stress

7 Anxiety

8 Genetics
Gene called 5HTTLPR polymorphism increases susceptibility for depression, it’s a serotonin transporter

9 Inflammation in immune system
Glymphatic system is link between immune system and brain
Inflammatory markers
Cytokines
TNF tumor necrosis alpha
C-reactive protein (high amount in autoimmune diseases)
Prostaglandins (causes intense cramps in menstrual cycle)

Pharmacological changes
1 Focus on changing some core biological function (traditional methods)
1 TCA and MAO increase levels of norepinephrine/noradrenaline in the brain
2 SSRI does not increase amount of serotonin, just increases efficacy of serotonin that’s already there

2 Rewire neural circuitry (newer methods, research currently being done in these fields, highly regulated and done in controlled setting/controlled dosage)
1 Doing things to NMDA receptor, impacting layer 5 neurons in neocortex
a) Ketamine and PCP block NMDA receptor, antagonist
Ketamine, change the spines on neurons in the prefrontal cortex, increases neuroplasticity, and changes in how we think, feel, and behave
Dissociative anesthetic states, emotions don’t weigh so heavily, shift in neural circuitry

b) Psychedelics
Psilocybin aka magic mushrooms
Layer 5 neurons in the neocortex – first layer of brain, connects to different areas of the brain, serotonin 5h2a receptor is there
Helps the person to exist in past present future, helps them find solutions to what’s bothering them

c) MDMA for trauma

Ketamine is more for distancing
Psilocybin is for immersing self

Lifestyle changes
1 Creatine
Helps with exercise output, might be bad for kidneys

2 Food
Omega 3 fatty acids good you, relief from depressive symptoms
Amino acid Tryptophan converted to serotonin
Fermented food good for gut bacteria
Ketogenic diet can help with pediatric epilepsy
Increases GABA transmission, it is inhibitory neurotransmitter
Alcohol increases GABA, lower social inhibitions, suppresses self-monitoring pathways
Also, benzodiazepines, Xanax, and valium increase GABA transmission

3 Exercise

the incredible how i want to pay so much more attention because the intense eye contact level. it's like he's talkin right to me and i just wanna focus on just him explaining it. @andrew is it with that eyecontact AI tech? kidding but what do your notes look like for these?

Everybody is equal in and life and death. Depression affects all of us at some point .

This Is so lame and fake, doesn't relate at all to real depression. I couldn't connect or relate at all with this fake video

The RX part of this is interesting. In a Major Depression episode where a person experiences all the above symptoms is there 1 magic pill or are doctors tending to prescribe a plethora of them to combat the symptoms?

I eat well, blood work is perfect, health is great, I’m just always tired. No reason for the fatigue, I live a healthy lifestyle limiting screen time… I’m just always exhausted. The only time I feel good is every couple of months I fast for a couple days.

I swear by Fish Oil Supplements 💯

Dr Huberman, thank you for your podcast. What about farmacogenetics for the tratment of mood disorders or other psychiatric diseases? Thank you

As a paramedic from Australia, I continue to learn from your amazing podcasts.

Dr. Huberman's technique, "avoid dopamine highs," look like it is working for me. I stopped watching porn. Even though I never do it beyond 2 hours per session and per day, which I believe is not too much, I suspected that it still probably made me sick. So I wanted to see what happens if I stop it. After just 5 days of stopping it, there is a small but recognizable difference in my mood. First I felt better about myself and my self-control, and then noticed a tiny spike in motivation to go and change my life. I will continue it and post results.

I got out of depression and fell back into it. I was so sad. I think I’m stressed and also in anxiety mode because of where I live. I don’t find pleasure here and my home I wish I will find pleasure over there when I go. God help me.

Was gonna listen but when you're trying to sell stuff on the back of it. Forget it.

Lots of notes taken. I will get it going and see where this takes me.
Consistency will be the key.

Hi, we actually have a group of people that we help to battle Anhedonia, now their Anhedonia was caused by SSRI medications and COVID. What happens then when Anhedonia wasn’t created by an excess of dopamine ?

Learning about mechanism has helped me understand myself and the world
I find it fascinating and immensely validating

Thank you for validating my life experience. Your discussion about episodes of stress related to depression- explains what I have been through and how I ended up in a severe depression. Long story here but the pathway makes a lot of sense

You are amazing ❤ Thanks for this episode as it helps me to understand better this condition, in order to help someone who is close to me . Thank u for sharing your knowledge and experience . You are 1 in a million ❤

Love this guy

Can you help with what brands of EPA and creatine is good quality?

Excellent podcast. Exactly what I was looking for. You are the best! Thank you.

I love that Huberman truly does stick to the science. Nothing really philosophical, moral, nor opinion based. Purely fact driven. It’s such a breath of fresh air.

I'm so glad to have discovered these conversations and find them incredibly useful with my clients to help them learn about how their own psychology and bodies work in conjunction with each other. Thank you for sharing your valuable knowledge.

Oh Dear God😲, TWO HOURS ---
I'll Forget The First Hour, Going Into The Second Hour😬😁

Thank you so much for your informative podcasts, Dr. Huberman. I'm currently dealing with potential physiological symptoms of stress-induced depression. Understanding the mechanisms helps me feel more confident in my ability to push back against the affliction. Your work is important- thank you again.