Identical Twins with Multiple Sclerosis

This video reveals the research on identical twins with multiple sclerosis. When the effect of genes is removed, the importance of other environmental factors is apparent. What is the risk of MS if your identical twin has it? When identical twins both have MS, is the disease course and severity the same? When twins are discordant (one has MS and the other doesn't), what are the observable differences between them? I also tell the story about 4 of my own patients, 2 sets of identical twins.

Selected Sources:

Multiple sclerosis in twins: https://www.neurology.org/doi/10.1212/wnl.30.11.1139?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmedTwins Support Each Other Through Multiple Sclerosis Diagnoses: https://atriumhealth.org/dailydose/2023/03/22/twin-sisters-diagnosed-with-multiple-sclerosis
Twin concordance and sibling recurrence rates in multiple sclerosis: https://www.pnas.org/doi/10.1073/pnas.1932604100
The British Isles survey of multiple sclerosis in twins: https://www.neurology.org/doi/10.1212/WNL.44.1.11
Multiple Sclerosis Study With Twins Untangles Environmental and Genetic Influences: https://neurosciencenews.com/genetics-environment-ms-20081/
HANDEDNESS, WITH SPECIAL REFERENCE TO TWINS: https://pmc.ncbi.nlm.nih.gov/articles/PMC1209084/pdf/178.pdf
Comparison of the Concordance of Allergic Diseases between Monozygotic and Dizygotic Twins: A Cross-Sectional Study Using KoGES HTS Data: https://pmc.ncbi.nlm.nih.gov/articles/PMC10220535/
Effect of Epigenetic Differences in Identical Twins: https://www.researchgate.net/publication/320386487_Effect_of_Epigenetic_Differences_in_Identical_Twins

Concordance for Hodgkin's Disease in Identical Twins Suggesting Genetic Susceptibility to the Young-Adult Form of the Disease: https://www.nejm.org/doi/full/10.1056/NEJM199502163320701
Twin concordance rates for rheumatoid arthritis: results from a nationwide study: https://pubmed.ncbi.nlm.nih.gov/8402000/
A revised estimate of twin concordance in systemic lupus erythematosus: https://pubmed.ncbi.nlm.nih.gov/1536669/
Parkinson Disease in Twins: An Etiologic Study: https://jamanetwork.com/journals/jama/fullarticle/188406#joc81035f1
Deep DNA metagenomic sequencing reveals oral microbiome divergence between monozygotic twins discordant for multiple sclerosis severity: https://pmc.ncbi.nlm.nih.gov/articles/PMC7301750/
Viral Antibodies in Multiple SclerosisA Nationwide Co-twin Study: https://jamanetwork.com/journals/jamaneurology/article-abstract/590207#google_vignette


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Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.

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he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.

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#multiple_sclerosis_twins #ms_twins #multiple_sclerosis_research #ms_research #multiple_sclerosis_genetics #ms_genetics #brandon_beaber #beaber

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