p53 Tumour Suppressor and MDM2

Do you do the voiceovers for Sketchy?

This is amazing. Thank you so much

Great job ❤

Awesome this is what i needed to know

Soooo when p53 permanently arrests a cell but does NOT induce apoptosis does that mean the cell is senescent? Just sort of hanging around and getting in the way but otherwise causing no harm?

I love the creativity of your videos.

I have a question. I know that in order for cell arrest to occur, p53 and mdm2 have to be phosphorylated in order to inhibit their interaction. But what kinase facilitates this reaction?

Thanks for making an easy to understand and entertaining video. I'm curious why, when certain nutlins are used to inhibit MDM2, patients with myeloproliferative neoplasms see a transient rise in P53 mutations. A rise in P53 mutations appears to correlate with progression to higher risk accelerated/blast phase and AML, meaning that while MDM2 antagonists may offer apoptotic benefit, they may concurrently accelerate accumulated mutations as well.

Great one!

Thank you ❤️

video molto utile. Grazie!

p53 does not function according to the 2 hit theory. Since it's active form is a tetramere, a mutation to 1 allele of the p53 gene would make it so that 15/16 active p53 complexes are disfunctional and only 1/16 is effective. 1 mutation is enought to create a significant loss of function

Can you make a video specifically on the RCP?
Replication Control Point, or just the control points in general: DDCP, RCP and MCP

Does p53 inhibits the activation of those genes responsible for apoptosis or overexpress them???
confusion.

will you make a video about oncogenic viruses ???

explain apoptosis

Thank you!

it was really easy and perfect!!!

PLEASE make video on glycolysis, TCA cycle ond oxidative phosphorylation

Amazing animation! It helps a lot

This is a great video, very clear and with lots of content

Could you explain BRCA 1 and what happens when it is mutated

how did I end up here

That was really informative! Thanks a lot from Iran.

Awesomely done.

That helped a lot! Best wishes from Germany 👍🏻

Excellent!

Mach auf Deutsch du arschloch

Hi, nice video!
I hope this is not a dumb question. I think I get the gist of p53 ie. It's a type of QA inspector for DNA and if dna Damage exists it triggers cell death or senecense. What I don't understand is how and what 'damage' is detected?
What gets spotted as 'not right'?

Eg. if you were a QA inspector for say chairs you might count the number of legs, check the lengths of the legs were equal, check the thickness of the legs etc to determine whether or not to reject the chair.

Kind Regards, Simon.

Absolute life saver!

Nice explanation!!! Thank you so much ♥

Presentation is awesome

wrong information! mutation in only one allele/ heterologous mutation can leads to non-functional p53. this is the unique feature of p53 compared to some other tumour suppressor genes. this is why p53 mutation is so prevalant in cancer

Found this exactly a year later and it is still as useful! Thank you! :)

Awesome content! Great use of visual cues, microphone could use an upgrade!

You just saved me!
Very comprehensive and concise. Can I just ask, if you don’t mind, what sources you have read, related to this video?

Thanks !

Awesome! It truly helped me understand the regulation of the cell cycle (in addition to your other video about cyclins). I'd been reading about it but didn't truly get anything... until I found your video, thanks!!! loved it <3

brilliant