Heme Catabolism and Degradation Pathway - Biochemistry Lesson

Thanks

Great video!!!!:))))

Thank you so much❤️

Very helpful♥️

Can i make screen shots of some images of this vedio and use it to teach my students in the class?
I seek ur permission please.

Good presentation

Awesome! Thank you!

Helpful,
thanks.

I really appreciate the class

perfet ,keep it up man

Perfect,thank you

❤️

Dear JJ Medicine
Your way of explaining is marvelous, from your video my confusion is cleared now , but kindly please tell me that from where you read this text that ( when RBCs/Erythrocytes disintegrates/ ruptures / splits then hemoglobins hemoglobins will be comes out from Erythrocytes) I mean say that please sheer book name / website address because I want reference because from your video my half work is done but half will be done after attain reference .

Regards wahm farad

Thanks sir from your video my confusion is clear now.

great.god bless you

Thanks for this video!!

Very helpful thank you 😊

GREAT ANALYSIS SIR 👍 👏

this is awesome !🤩👏

I try to deliver hemin through nanoparticles form to kill cancer cell....but it does not induce toxicity. Why it does not induce toxicity in the form of nanoparticles form????..
Please reply

woooow.... thank you very much

Thank you , a summary of 3 hour class

Cool!!! Thank you so much

Trivial lecture. NO DETAILS about water and lipid solubility / who gives a damn about "discoloration discolaration" all over the lecture you nuttard...........

Dang finally someone who can explain this in a way that makes sense!! You're a lifesaver bro. Great vid

This was by far the most easiest video made on bilirubin metabolism.......loved how simply sir explained it❤❤❤

Great information thanks

Thank you for the nice lecture! I love your videos and really learn a lot from them. Maybe you could answer these questions I got regarding this topic.

From what I've gathered, bilirubin is metabolized in the intestine bacteria who unconjugate bilirubin and it goes back to its original structure. Then they metabolize bilirrubin down to urobilinogen and then it is either excreted as stercobilin or reabsorbed and only some of this reabsorbed part is excreted in the urine as urobilin.



So I have 3 questions:
1 - Why is only urobilinogen reabsorbed? (i.e. in the absence of obstructive jaundice, there is never conjugated bilirubin in the blood unless there is backflow of bilirubin from the bilicanaliculus down to the common bile duct; and to the best of my knowledge we can't reabsorb unconjugated bilirubin and its metabolites except urobilinogen). Presumably, unconjugated bilirubin is not able to diffuse tissues despite being unpolar because it's too big but do we have a specific receptor for urobilinogen?
2 - Why don't we excrete stercobilin in the urine and urobilin in the stool? Is there different enzymes for both that are differentially expressed by bacteria and human tissues? It is also interesting that we seem to be able to metabolize urobilinogen into urobilin but only bacteria can metabolize conjugated bilirrubin down into urobilinogen.
3 - What pathways do we use to transport and metabolize urobilinogen back into conjugated bilirubin in hepatocytes? (Because although human cells cannot produce urobilinogen, it is well recognized that through enterohepatic circulation, the majority of urobilinogen reabsorbed via the portal system is reconverted into conjugated bilirubin.)

Thank you so much, much appreciated

thanks , it was great

Thank you so much!

Thank you it was awesome!

Thankkk youuuu

Really good video

what would high ferritin and high bilirubin mean? also normal to high hemoglobin!

i m not a person who usually visit comment box but your effort made me do so. doin gr8. stay blessed sir

This video is a very informative and easy to understand. Thank you very much.

it's urobilin not stercobilin

IT's Fe3+ not Fe2+

thanks a lot

that was great

This is really helpful. Thank You ☺️

i love the extra info that you added sir. thankyou it was very helpfull

Tons Of Thanks 😍

Very very very helpful videos !!! 👍

I'm a second year med student i found very useful to understand the basic mechanism and to get familiar with the terminology thanksss

You're the best!

this seamlessly summarized an hour long lecture. God bless you sir

Thank you.

I'm a 1st year medical student and I REALLY ENJOYED this video! you did a great job! Thanks so much!