David Sinclair: Extending the Human Lifespan Beyond 100 Years | Lex Fridman Podcast #189

WEndy and Lex. Best lovers. Married 9/8/2023. Lord bless us with children as numerous as the stars@ in yh÷ sky. ❤❤❤😂😂😂😊😊😊🎉🎉🎉🎉🎉🎉😢😢😢😮😮😮😅😅

Imagine enjoying the life but wanting to die (not being inmortal)

it was coming face to face with mortality, and in particular the stark raving terror of my possible non-existence, that caused me to KNOW there had to be 'something more'. or why would i be so paralyzingly ~afraid~? and i don't simply mean a greater recognition of 'sweeter moments'. or trying to psyche myself into being more appreciative of life when i'm not. thank God (literally) i found the truth of the immortal life of the soul for all in the message of the love of God through Christ Jesus. which, none of us ever die. we simply slip off these old coats and carry on.

I would appreciate a response to Dr. Charles Brenner's Article "Sirtuins are not conserved longevity genes" Life Metabolism, Volume 1, Issue 2, October 2022, Pages 122–133.

Dr. Sinclair advocates a Fountain of Youth with questionable evidence to support his theory of aging. Have other scientists tested Dr. Sinclair's new theory of aging? Given the history of questionable claims to resveratrol extending the life of laboratory rats has been seriously challenged, should we be thrilled by this theory.

Been following his research for a year now. I’m
Hopeful in his research.

People dont need to worry about ai.. because people put so much stupid information out there that ai will be an idiot.

Shocked to find out he’s 53, he looks late 30s

Who the hell is going to take care of all of these 100 year olds? We can't care for our elderly now.

that was luis CK in the last minutes. you should've mentioned him, even if he's a comedian and not a philosopher like the ones you mentioned.

This is gold! Lex, I suggest you listen to this again and overthink some of your views. I agree on so many points with David here.
Especially, please consider a more healthy (plant based) diet, not only for your health but also for the planet.
Thanks for doing these interviews!
Much love from NZ, Chris

You so handsome Lex

As long as the experimental phase on humans doesn't look anything like what happened with the covid vaccines

I wonder how much of this cutting edge tech to keep us young and living longer will drip down to the common people.

Lex asks a question, and then adds context, and then keeps talking about why his question is relevant to him, and it's very frustrating.

Initially it's some refreshing insight, but now I just fastforward to the guest answering the question which was asked two months ago.

I am 35 or something, my body screams NOOO every day, i feel like the ghost trapped in the body of an old man, yet people expect me to behave like a healthy person, i can not imagine how hard it must be for people with disabilitys....this is some bullshit for privileged people who never worked in their life.

Geez Lex always does his homework for the topic of the day. Some complex areas of Science.

Thanks for introducing me to David Sinclair. Just downloaded his book on Audible. Cheers Lex!

This dude looks like he was taken out of The Addams Family Cast...

I like that fluffy porcupine.

Great all the greetings rich people will live longer

Brown noise is ligit

All I want is to choose when I die

Even one human living one day longer is exactly what this planet doesn’t need.

Lex is a sap... Sinclair (PhD) tried to foist Resveratrol (doesn't work) on the public. Then he lobbied the United States FDA to ban NMN (which does work) so he can develop it exclusively. What a joke.... They did of course. The FDA should be dismantled and reorganized.

Lots of interesting stuff here. For me personally, light fasting is something to look into. BUT, exercising more does not wear out joints, it strengthens and regenerates them even past middle age (so long as you are careful to avoid injury and work on mobility - that does not get enough attention). Berries have beneficial antioxidants, and fruits key nutrients (just don't eat too much); meat, too much is bad for you, red meat among the worst things you can eat if longevity is your aim (Lex, Lex, Lex ...I worry for you!). Just funny that, without exception, specialists in aging or performance will pursue things that other studies show unequivocally are incorrect or sub-optimal, and. conversely, avoid or downplay beneficial things, usually in the name of pursuing some metric that they have targeted (no sugar is a good example here). Moderation in all things! It still works mots of the time.

I have to say I'm puzzled that in these casts on longevity, performance, etc., the Mediterranean diet rarely comes up. (Sinclair touches on this at about 59 min.) Yet it's the only one that has unequivocal impact on health and longevity, supported by decades of studies. Would like to hear more on this.

David Sinclair is a complete and total fraud conman. He uses platforms like Lex's to get interviewed by someone completely ignorant of his field and is unable to challenge him in any meaningful way so he can spout his BS and sell his snake oil. He did the same thing with NMN and resveratrol. Don't believe it.

those molecules must be working, because David has a the brain of a 15-year-old!

Sinclair's lobbyist and patent attorney recently forced all forms of MNM except the form Sinclair now owns a patent on - to be taken off Amazon, etc. He now has a monopoly on the compound.

If that assertion is true, then that little bitch sickens me as he talks about what he wants to do for humankind on this podcast.
Lex, fortuitously lives in a make-believe world about love and the nature of human kindness. But Sinclair is much richer for accomplishing the alleged con. Lex, of course, is a perfect patsy not to challenge Sinclair on the numerous published paper that refutes Sinclair's assertions on his monopoly product.

Most people - how to slow down aging
Some of us - how to reverse aging
Legends - Bringing people back to life..

David Sinclair
Born: June 26, 1969 (age 53 years)

... That's what a 50y+ man looks like ? Just look at his face ..

If there was to be a backup there would have to be a mechanism to access it, probably through behaviour or environnement influence

Since this interview David Sinclair and his company have successfully lobbied the FDA to have NMN banned as a supplement, citing its investigation as use as a ‘drug’. Also he wants to make humanity better because his grandma told him to.

The brown and white noise they talk about is related to transcendental meditation I believe, and very beneficial as Lex stated.

We will be the last generation, we give birth to the Eternals, It won't be us, but our kids.

I'll probably never see any of you in person, but I love you all, thanks for making this temporary immortality great

This is probably my favourite ever podcast. Could listen to these two all day. I can’t remember the last time I questioned my perspective so many times in a short amount of time 😂

Oo

What is this test he talked about that can detect cancer 10 years early? I want that test.

He needs to deal with the resveratrol controversy. It bothers me to see someone without conscience willing to repeat self interested promotional statements when he already has the means. Whats the motivation at this point to be open about whats true and desregard whatever ego he has on the subject.

Insurance companies refuse to cover people
This is not good

I have 😮

I so agree with Lex when he talks about doctors being pretty much negligent about collecting datas, and often doing diagnostics based on %.
I'm 38 now, training a lot, and running (did half marathons and marathon). I've been on antidepressants for 10 years, I stopped this year. It's a struggle, been I'm trying to be living naturally. I've been given meds but never have they check for my testosterone levels and other potential key elements that contributes to anxiety and depression. This video inspire me To work on staying healthy and trying to be stress free.