The Science of MDMA & Its Therapeutic Uses: Benefits & Risks | Huberman Lab Podcast

Thank you Sir!

I took Mdma in a clinical setting. [Doctor reccomend] and wow! My major anxiety disorder vanished immediately after my first visit. Its like somebody turned off a light switch. This was 7 months ago. Never had to go back. Doctor wants me to go for more sessions but I simpley don't need to. Truely a blessing. It's like Mdma healed my brains imbalances. 🧠

Pure MDMA is the BEST. Really helped my relationship. But way to hard to get real MDMA in the states which is a damn shame.

Great information👍

Love it🔥👏

Molly changed my life For the better ❤️ your not supposed to take it more than once a month listen to your body you know when you shouldn’t do more just like any other drug gotta have self control and yea you can hallucinate on a big dose doofus I have before you got a lot of facts wrong 😆

MDMA is technically natural because it comes from MDA which comes from the sassafras plant

Not for illegal use of it, but i m big on therapeutic use of MDMA.

I'm curious now if oxytocin potentially has a synergistic effect in conjunction with levels of dopamine and serotonin. Maybe a study involving individuals given MDMA with a sub group given an additional dose of nasal oxytocin...🤔

started microdosing mushrooms in place of my prescriptions and the difference is night and day in my mental health and my anger i feel like ive become a better person best decision ive ever made wish it was more accessible to those that need

Shoutout Alexander Shulgen for helping us rave 😂

One of the most brilliant but at the same time never straight to the point man!
Sooo much fluid words with small to no meaning for the general public!
Definitely need someone to summarize it for a dummies like myself

If you take MDMA every 3-4 months, can it be considered an addiction? People write that MDMA does not cause physical dependence, since it is impossible to use it often, since it will not have the desired effect, but nevertheless they do not stop after the first dose and those who manage to control its consumption still continue to think about it and wait with I'm looking forward to next time, I understand that we drink alcohol much more often, which is not good, but for me the danger is that alcohol makes me feel 3-4 points good, and MDMA makes me 10, and I have a feeling that I will never give up MDMA , since alcohol and marijuana do not bring such emotions, I have never consumed anything other than alcohol, grass and MDMA in my life, I used MDMA about 5 times in 3 years in its pure form, share in the comments who else has such thoughts in their head and maybe I should forget about MDMA forever and not take it, because I’m really afraid that I won’t be able to have fun as things are going before taking it, share your thoughts or experiences with me in the comments, thank you for reading to everyone!❤

I tried it at a club for the first time, 2/3 of a pill with a bite out of an edible. Taking the two together was clearly an error and my threat detection apparently went all wrong because I eventually got paranoid thinking everyone was against me, and seeing every happy face or word as agressive. To this day, 7 months later, I still struggle with this psychosis.

Be smarter than I was.

MDMA forced me to open up and talk about my issues with my friend. Experience brought us together so much, pure honesty and openness.

Waltuh if he was a raver

love this man

Lots of illegal drugs have therapeutic properties including cocaine and heroin. That does not mean promoting them is a good idea. These channels have just sunk to the level of drug pushers.

I think the oxytocin rise is mostly coming from downstream effects of dopamine and seretonin and the perception of the experience that the user is having

"Suicide tuesdays" that deep depression after a weekend of molly wears off. It sucks!

Say it right!!!!!

Methyl amphetamine!!!!!!!

Does mdma effect testosterone ?

Watched the portion describing the chemistry and was quite disappointed. Not only is that not how you pronounce shulgin, that's not how you pronounce phenethylamine. Mispronunciations aren't too concerning. What is tho, is the lack of explanation/detail about the stereochemistry of MDMA.

MDMA has a chiral center, meaning that there are two "mirror" versions of the molecule, that can/do exhibit different pharmacology, because the two "mirror versions" (isomers) are actually different drugs.

SO MDMA is not one drug, but 2 drugs. The D and L iosmers. (Alpha carbon, methyl group)

Just like dextroamphetamine and levoamphetamine have different effects and pharmacological effects, dextroMDMA and levoMDMA have different effects, and pharmacological effects.

Is the MDMA being used in these studies dextro? Levo? racemic?? Because that matters! If you are using racemic MDMA in these studies, you are in fact testing a combination of two different drugs.

This is a big deal, isomers matter, and making it clear that most MDMA available (is racemic) and is a combination of two different drugs, dextroMDMA, and levoMDMA is incredibly important.

DextroMDMA could be therapeutic, and levoMDMA could be nuerotoxic or vice versa, we don't know yet. So to say MDMA causes anything is misleading, because we need to know what individual isomer is causing which specific effect. We need to examine and talk about the individual isomers, rather then racemic MDMA.

Also, I didn't watch the whole thing, but did he talk about how MDMA metabolizes into MDA, another entactogenic amphetamine?

Amazing video! I am left with a question though: the dosis of 1mg-1.5mg x bodyweight is mentioned a few times as the (relatively) safe dosis, does someone know the reasoning behind this number? I have heard the number before, but I know for a fact that some of my friends (recreational users) far exceed this number, I would like to be able to explain to them that sticking to 1-1.5mg is better.

I just finished seven infusions of ketamine, it helped my depression also have PTSD. I am interested in mushrooms are legal at this time in the United States?

i used MDMA last Month 3% in 1 gram now it's showing some problem in body?

I’m an a pill

Can you do a podcast on GHB?

i struggled 2 years of depression. i did not want a anti depressant, because it reduce not solve! and addictive. i also did not want street MDMA, so i did hours of homework online, and came across 6-APB 100MG tablets legal online. i took 6-APB and for 50% i felt better, i waited another 2 months and took the second 6-APB and believe it or not but i was depression free! and still am. even i cannot still believe it that only 2 tablets 6-APB saved and cured my life after 2 years of hell!

So you're a mattress salesman? What a joke

Thank you. A very interesting and accurate report, I have had various experiences, even not very edifying ones, on the topic, in 2023 a 360° objective point of view on the topic and accurate and simple explanations even to people who are not in the sector 💯👍

I feel that Mr huberman did aome experimenting of his own around the period of doing this podcast . I may be wrong

I really like the video I saw an article today called ‘’Pre-rolling’ and ‘Post-Rolling’ for MDMA to enhance the experience and reduce negative effects’’ the article suggests some supplements that might reduce the risk of the mdma effects can you check it and tell me ?

Thanks! Amazing compilation

I wanna party with Andy

My wife and I both did a therapeutic session and it completely changed our own individual agency and it changed our relationship in the most amazing ways!!!

The history of MDMA... a whole pile of bullshit. It came from China then EU, not US ROFL. This story is way to much USA'd.

This is my favorite kind of person.

How about an episode about Ayahuasca? It’s a powerful tool for healing trauma

Has Dr. Hubermann taken MDMA?

You said about propositions. I checked channel and I did not found anything about Internal Family Systems.
You mentioned about side effects of PTSD treatment and indeed many of the psychotherapy modalities has that's "retraumatization effects" which are successfully ommited in IFS method. I'm working as a psychotherapist in that system and I can confirm that my client don't meet to go through the traumatic events once more, but still can release the burdens and suffer using this method.
I strongly recommend author of the method Mr Richard Schwartz or Robert Falconer. Both are experienced and has huge knowledge about the method and human psyche.

Did he say how often is it more or less safe to do mdma? I’ve heard once a month but I wonder if once a week would occasionally be ok, and how long does it take for the brain to bounce back from the crash.