Reasons & Solution Of Over Wetting Defect In Granulation

Over wetting is one of the most common & practically observed defects during the wet granulation process.Over wetting is the condition where our powder materials become more wet or a doughy mass is produced in RMG or in the ribbon or plough mixer.
In this video we have discussed the following
What is over wetting?
Reasons for over wetting defect?
How to prevent over wetting?
Drawbacks of over wetting?

Reasons for Over Wetting
Most commonly observed reasons for Over Wetting are given below
Excessive amount of solvent
Increased kneading time

Over wetting is usually observed during the manufacturing of the first batch of new product or during 1st validation batch of source change because we have no historical data of solvent quantity on a large scale.
Watch the complete video to learn why over wetting defect occur after completion of validation batches.

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Steps of wet granulation
https://youtu.be/DCUENHeY3C8?si=hfAnuaadD2Tncxet

Wet granulation playlist
https://youtube.com/playlist?list=PLUxlpXj8PXVpU6F3W6qDyfX50WrpWfcbl&si=_iBSt5I2CAkst876

Tablet granulation defects
https://youtu.be/9Fjl8mxFfNI?si=FpTGMTJ6YTlgqPvZ

Тэги:

#Granulation_over_wetting #reasons_of_granulation_over_wetting #solution_of_granulation_over_wetting #Granulation_defects #drawbacks_of_over_wetting #tablet_manufacturing_defect #Kneading_time #doughy_mass_in_wet_granulation

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