The Immune System of Bacteria: Beyond CRISPR

The arms race between bacteria and phages led to the development of sophisticated anti-phage defense systems, including CRISPR-Cas and restriction systems. We recently discovered that the microbial pan-genome contains many new defense systems whose function was so far unexplored. The talk will describe the mechanisms of action of recently discovered new anti-phage systems. Surprisingly, our studies show that bacterial defense from phage gave rise to important components in the eukaryotic immune system. Objectives: * To understand the basic principles of the bacterial immune system * To learn about new developments in the field of bacterial immunity *To learn how components of the human immune system have evolutionarily originated from bacterial defense systems
See https://www.weizmann.ac.il/molgen/Sorek

For more information go to https://oir.nih.gov/wals

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